STUDIES ON I131-TSH: THE INACTIVATION OF TSH BY ELEMENTAL IODINE
نویسندگان
چکیده
منابع مشابه
Folding-dependent binding of thyrotropin (TSH) and TSH receptor autoantibodies to the murine TSH receptor ectodomain.
The mouse TSH receptor ectodomain (mTSHR-ecd) was amplified from murine thyroid complementary DNA and ligated into the pAcGP67B insect cell vector, and the nucleotide sequence was confirmed. Employing a baculovirus-insect cell system, the mTSHR-ecd (amino acids 22-415) was expressed as a fusion protein with the gp67 insect cell signal sequence at the NH2-terminus and a C-terminal six-histidine ...
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The mechanism by which the thyrotropic or the thyroid-stimulating hormone (TSH) causes such marked growth and accelerated function of the thyroid remains a perplexing problem. Significant experiments in this direction have been reported by Rawson et al. (6, 8) who exposed TSH to slices of various organs in tissue culture. Of the various tissues studied, only thyroid, thymus, and lymph node were...
متن کاملTSH screening
That means there is considerable overlap in what we would consider the true euthyroid state in a patient. Hence, a population may be well characterised by this screening process, but it doesn't closely reflect the individual situation. As a result, an abnormal result of the population-based screening should not necessarily translate into an automatic decision on the requirement of treatment. Th...
متن کاملResistance to thyrotropin (TSH) in three families is not associated with mutations in the TSH receptor or TSH.
Resistance to TSH (RTSH) is a recently described syndrome of reduced sensitivity to TSH that manifests as euthyroid hyperthyrotropinemia. It is usually identified at birth during routine neonatal screening for congenital hypothyroidism. In less than 2 yr, 13 subjects with RTSH belonging to 8 families have been reported, and all were shown to harbor mutations in the TSH receptor (TSHR) gene. We ...
متن کاملIntracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance.
TSH resistance is one of the causes of congenital hypothyroidism with thyroid gland in situ. We recently identified families with dominant transmission of partial TSH resistance due to heterozygous inactivating mutations in TSH receptor (TSHR) gene. Although we documented a poor routing of TSHR mutants to the cell membrane, the mechanism responsible for dominant inheritance of partial TSH resis...
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ژورنال
عنوان ژورنال: Endocrinologia Japonica
سال: 1964
ISSN: 0013-7219,2185-6370
DOI: 10.1507/endocrj1954.11.275